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We show that replacing the R140, N141, L142 and W145 residues with alanine or deleting residues 129148 of the disordered linker region of STX7 decreased binding to Munc13-4 in TR-FRET assays (Fig

Additionally, through the action of SSAT, spermine can be used to generate N1-acetylspermine and N1-acetylspermidine, which act as substrates for PAOX and are converted to spermidine and putrescine

More recently, the gut has emerged as a central organ at the intersection of sleep, redox biology, and aging (Homolak, 2023)

While their corresponding flavones, chrysin, apigenin and luteolin, are not identified as copper chelator, Kubo et al

Inhibiting NF-B reverses SASP and delays aging-related pathologies via IKK/NF-B inhibitors (e.g., 8K-NBD) or phytochemicals such as curcumin and resveratrol