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A typical combination of symptoms (including fatigue, cold intolerance, weight gain) is the result of generalized reduction in metabolic processes and/or the accumulation of matrix glycosaminoglycans in the interstitial spaces (coarse hair or hoarseness of voice) [14]

Population analysis further showed that SLO-MO neuronsa brainstem path integrator known to encode positional information through persistent activitydisplayed both reduced neuron numbers and shortened activity time constants

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HIF-1 is a mammalian transcription factor expressed uniquely in response to physiologically relevant hypoxic conditions [52, 53, 56, 64, 67, 7081]