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Cholesterol is essential for maintaining intracellular homeostasis [55], and elevated cholesterol levels within tumor cells play a crucial role in enabling evasion of immune surveillance and fostering the upregulation of inhibitory immune checkpoint genes, consequently impeding the efficacy of antitumor responses [56]

Molecular Cell Biology, 25(1), 1333

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The T h 1 response is dominated by cell-mediated immunity, and delayed hypersensitivity (cytotoxic T cells) is initiated through macrophage production of IL-12 followed by production of interferon (IFN)- by T h 1 and natural killer cells