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However, as an opioid, loperamide has potential side effects, including the risk of opioid dependence and gastrointestinal disturbances

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Acute or chronic

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While normal mitochondrial metabolism produces ROS, they are managed by cellular antioxidant systems

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Therefore, various strategies to improve their therapeutic efficiency (application of other anticancer effects of cyanine dyes, improvement in the tumor selectivity of cyanine dyes and their combination with other therapeutic agents and therapies) are intensively studied

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Despite the initial shift toward glycolysis, microglia in advanced stages of Alzheimer's disease experience a decline in both glycolytic and oxidative phosphorylation pathways, resulting in a state of energetic exhaustion that impairs their ability to clear debris and protect neurons (103)

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