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6.1 Mechanism of action of food bioactives on gut microbiota and inflammation Food bioactives such as polyphenols, flavonoids, and other bioactives demonstrate potential in ameliorating metabolic syndrome through multifaceted mechanisms (Afolabi et al., 2022

doi: 10.1038/s41586-020-2634-9 228 BuscarinuMCCerasoliBAnnibaliVPolicanoCLionettoLCapiMet al

Comp Biochem Physiol 120A:4349 Lu FC (1996) Basic toxicology

389,390 Moreover, improvements in CRISPR-Cas9 technology present opportunities for accurate genetic and epigenetic alterations to rectify inherited genetic variants and epigenetic markers associated with DPN