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However, when the cellular iron content is low, this interaction is inhibited, stabilizing NCOA4, which in turn increases ferritinophagic flux and iron release in lysosomes (78)

Moreover, ceftriaxone-pretreated CLP group showed only 40% survival until 12th day

Early-life LPS exposure induce microglial activation and triggers persistent DA neuron loss from infancy through adulthood, with maximal vulnerability observed at embryonic day 10.5a critical developmental window for DA neurogenesis (Zetterstrm et al., 1996)