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Poster Session I - RECOVERY, REHABILITATION AND OUTCOME 03.00 - RECOVERY, REHABILITATION AND OUTCOME - 03.04 - BRAIN REORGANISATION AND RECOVERY P253 - ESOC25-737 INVESTIGATING THE ROLE OF MICROGLIA-T CELL CROSSTALK IN THE LONG-TERM SEQUELAE OF ISCHEMIC STROKE Chantal Dembech 1 , Julien Serrier 1,2 , Damien Levard 1 , Myriam Abioui-Mourgues 1 , Romain Goy 1 , Gizem Ocal 1 , Maxence Plateau 1 , Veronique Agin 1 , Denis Vivien 1 , Olivier Toutirais 1,2 , Marina Rubio 1 1 Normandie University, UNICAEN, Institute Blood and Brain @Caen-Normandie (BB@C), INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND)GIP Cyceron, Caen, France, 2 Laboratory of Immunology and Histocompatibility Caen University Hospital, Caen, France Background and Aims: Many survivors of ischemic stroke (IS) not only face physical disability but also delayed onset of symptoms, such as post-stroke depression, fatigue, and memory loss

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Notably, postnatal use up to 18 months was not associated with these outcomes

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Three main VC biosynthesis pathways have been described (Fig