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Driven by genetic, environmental, and individual factors, mitochondrial dysfunction associated with elevated free radical (ROS) production cumulates in susceptible patients over many years

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5 Conclusion In summary, lobetyolin, a chemical derived from Codonopsis pilosula , successfully interrupted the detrimental cycle of hyperandrogenism, insulin resistance, and persistent low-grade inflammation in DHEA-induced mice with PCOS

On the other hand, rifampicin exhibits its toxicity by activating pregnane X receptor (PXR), leading to an increased generation of reactive intermediates with hepatotoxic and nephrotoxic potential [5,6,7]