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A variant ECE1 allele contributes to reduced pathogenicity of Candida albicans during vulvovaginal candidiasis

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These results support a model in which residues P88 and P91 mediate activation via the arr1-N site, while F75, N122, and I314 are essential for activation via the arr1-CC site

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Energy minimization was conducted with the steepest descent method (maximum force tolerance of 1000 kJmolnm, step size 0.01 nm), followed by 100 ps NVT equilibration (0310.15 K) and 100 ps NPT equilibration (310.15 K, 1 bar) using the Berendsen barostat