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involved cyclizing carnitine to -hydroxy--butyrolactone, then acetylating to form -acetoxy--butyrolactone, preserving the chiral center and enhancing detection sensitivity (Abreht et al., 2014)

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Estos metabolitos son inactivos ya que presentan inhibicin de las lipasas muy dbil (1,000 a 2,500 veces menos que orlistat) por lo que se consideran farmacolgicamente inactivos