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Runx2 gene expression is increased in human VSMCs (hVSMCs) by bivalent histone modification of the transcription enhancer trimethylation of lysine 4 of histone H3 (H3K4me3) and the transcription suppressor trimethylated histone 3 lysine 9 (H3K9me3)

[57] studied and acquired the antioxidant collagen hydrolysate using non-pathogenic Bacillus collagenase-type protease to ameliorate age-associated sarcopenia

In the present review, we summarize how the metabolism is reprogrammed in TC and discuss how metabolic targets could be exploited for diagnosis and treatment