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Notably, compared with WT-resistant groups, monotherapy and combination elicited diametrically opposed trends in Mrp1 mRNA levels in KO-resistant groups across hepatic, blood, and splenic specimens: ART alone decreased hepatic and blood levels by 15.86-fold and 2.51-fold (versus 4.45-fold and 5.99-fold increases with combination), and increased splenic levels by 1.91-fold (versus a 2.56-fold decrease with combination) (Table 2 WT-R 1 versus KO-R 2 )

doi: 10.1210/jc.2010-0191 53 StrangesSMarshallJRNatarajanRDonahueRPTrevisanMCombsGFet al

However, recurrent and untreated episodes can be dangerous and interfere with normal development

doi: 10.1002/jcp.26819 190 WangXXiaY

Recent advancements further highlight TMAOs role in activating PERK across diverse tissues