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1 Introduction Chronic obstructive pulmonary disease (COPD) is a highly prevalent, progressive respiratory disorder characterized by persistent airway inflammation, irreversible airflow limitation, and alveolar destruction ( Emerging evidence now positions ferroptosis not merely as a consequence but as a key amplifier of COPD pathology, particularly through its dynamic interplay with immune dysregulation ( 2 Ferroptosis: a novel form of regulated cell death Ferroptosis is a distinctive type of regulated cell death that significantly differs from apoptosis, necrosis, and autophagy

Chambers I, Frampton J, Goldfarb P et al (1986) The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the termination codon, TGA