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In osteoarthritic joints, features of the local microenvironment, such as acidic synovial fluid, accumulation of reactive oxygen species, and elevated expression of matrix metalloproteinases and proinflammatory cytokines, accelerate cartilage degeneration and synovitis (Yao et al., 2023)

Vitamin D, often called the sunshine vitamin, helps regulate calcium absorption, strengthen bones, and support immune function

Dosage: Establishing the ideal dosage and timing for administering phytochemicals to realize therapeutic advantages for TBIs is a complex task, given that distinct polyphenols can have differing pharmacokinetics and mechanisms of action