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The role of NRF2/KEAP1 signaling pathway in Cancer Metabolism

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Finally, this pathway also modulates the tumor immune microenvironment through metabolic reprogramming, as illustrated in Figure 1

Even under normoxic conditions, OXPHOS generates free radicals (some of which are oxygen-based species) due to the leakage of electrons from the electron transport chain (ETC) when they are passed between the successive protein complexes (Figure 4)

Whether they compensate for each other in OA or play dominant roles at different pathological stages remains an unknown area