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It plays a role in promoting fat oxidation, improving glucose utilization, and supporting exercise performance in preclinical and early human studies

Research Overview Nicotinamide N-methyltransferase (NNMT) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing 1-methylnicotinamide and S-adenosyl-L-homocysteine [1]

The Governments 2016 National Diet and Nutrition Survey found vitamin B12 blood levels indicating deficiency in three per cent of girls 11 to 18 years, six per cent of adults 19 to 64 years, five per cent of men over 65 and eight per cent of women over 65

This is general education, not medical advice or a recommendation to use AOD-9604.

This does not make it the most effective, which remains debated, but it does make it among the best characterized for safety