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Sies, H

PLoS Comput Biol 13 , e1005752 (2017)

acidophilus produces SCFAs like acetate, which activate Intercellular adhesion molecule-3-Grabbing Non-integrin Receptor 3 (SIGNR3) receptor on dendritic cells, suppressing IL-6/STAT3 and RORt pathways to inhibit Th17 differentiation while promoting Treg expansion, helping restore immune balance ( L.plantarum and A.muciniphila secrete metabolites that bind TLR2, downregulating NF-B to block the IL-23/Th17 axis, Additionally, A

This is true for healthy individuals and as well as for the elderly or chronically ill who may suffer from persistent low glutathione due to an impaired enzyme that is the first step responsible for making glutathione inside our cells