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Huang W, Ghisletti S, Perissi V, Rosenfeld MG, Glass CK

Respir Physiol 2001, 128: 331348

Numerous in vivo and in vitro experiments have demonstrated that melatonin treatment has a significant effect on alleviating liver fibrosis (120).As the key effector cells in the process of liver fibrosis, HSCs can be activated under conditions of inflammation and oxidative stress, leading to excessive proliferation and transdifferentiation into myofibroblasts

In Figure 8(b), the simulation results, from integrating oxidative stress with the formaldehyde detoxification pathway of C1 metabolism, indicate that glutathione (GSH) concentration varies significantly with and without the presence of oxidative stress