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doi:10.1111/j.1467-789X.2007.00413.x Smith, R

Toxicology studies have shown no lethal dose (LD1) could be achieved in animal models, suggesting a wide therapeutic window

These targets were enriched in several signaling pathways, such as the cAMP signaling pathway, MAPK signaling pathway, and neuroactive ligand-receptor interaction pathway

J Appl Physiol

And the shared 4-week reconstitution clock means that if the experiment finishes early, the unused 60 percent of the blend ages out simultaneously across all three components