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In vitro studies, Tan IIA (1,3 and 10 M) downregulated the expression of SR-A and upregulated the expression of ABCA1 and ABCG1 by activating the ERK/Nrf2/HO-1 signaling pathway, thereby inhibiting ox-LDL-induced cholesterol accumulation in THP-1 macrophages (Liu et al., 2014)

doi: 10.1186/s12951-021-01094-x 295 GengXChenYChenZWeiXDaiYYuanZ

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Plasma folate was significantly decreased in the CrO+D group, which received dietary and overload creatine, compared with the control group, the no-creatine control