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Differential expression analysis was performed in R studio (R version 3.6.3) using the DESeq2 package with a q-value 1.5

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Sequencing was performed on the Illumina platform Novaseq X Plus at the Northwestern University NUSeq sequencing facility core, with a targeted sequencing depth of 20,000 and 25,000 reads per sample acquired for RNA and ATAC profiling, respectively

Coupled with endogenous reactive oxygen species (ROS) generated as by-products of various cellular processes, strict regulation of antioxidants is critical to maintaining a balanced reduction/oxidation (redox) state